SubB2M is an engineered protein that specifically detects the pan-cancer biomarker Neu5Gc that is found at elevated levels in multiple human cancers. INOVIQ is developing SubB2M-based tests for multiple uses, including monitoring of breast and ovarian cancers, and for a general health panel.
Cancer cells have a distinct feature of adding different sugar molecules to the proteins they produce, which sets them apart from normal cells.
One such sugar molecule commonly found in cancer cells is Neu5Gc. SubB2M preferentially binds to Neu5Gc. SubB2M is a promising multicancer probe. Incorporating SubB2M into existing cancer diagnostic tests, may improve their sensitivity and specificity in detecting various types of cancer.