Product Overview
About EXO-NET®
EXO-NET® is a fast, reproducible and scalable EV isolation tool for biomarker discovery and diagnostic development. To learn more, watch the EXO-NET® plasma EV isolation training video.
The EXO-NET® solution – Immuno-Magnetic Bead Based Capture System
Despite the explosion in exosome research and their potential in disease (especially cancer) diagnostics, exosome-associated biomarkers have not yet been translated to meet the rapid developments in molecular medicine for commercial liquid biopsy applications. This is primarily due to the limitations of current exosome capture and isolation methods, which are time consuming, operator dependent and not scalable. These limitations are overcome by using INOVIQ’s EXO-NET® technology.
Comparison of the key features in commonly used EV enrichment techniques1
| EV Enrichment Techniques |
Time |
Cost |
Scalability |
Recovery |
Specificity |
| Polyethylene glycol precipitation |
+++ |
++++ |
++++ |
++++ |
+ |
| Size exclusion chromatography |
+ |
+ |
+ |
+ |
+++ |
| High MW centrifugal filters |
++++ |
+++ |
++++ |
+++ |
++ |
| Differential ultracentrifugation |
+ |
++ |
+ |
+ |
++ |
| Tangential flow filtration |
+++ |
++ |
++++ |
+++ |
+++ |
| Affinity chromatography |
++ |
+ |
++ |
++ |
++++ |
| Immuno-magnetic bead capture* |
++++ |
+++ |
+++++ |
+++ |
++++ |
*EXO-NET® is an immuno-magnetic bead capture system.
1Extracellular Vesicles and Their Emerging Roles as Cellular Messengers in Endocrinology: An Endocrine Society Scientific Statement - Carlos Salomon, Saumya Das, Uta Erdbrügger, Raghu Kalluri, Sai Kiang Lim, Jerrold M Olefsky, Gregory E Rice, Susmita Sahoo, W. Andy Tao, Pieter Vader, Qun Wang, and Alissa M Weaver. Endocrine Reviews, 2022, 43, 441–468.
INOVIQ’s EXO-NET® allows for improved purity and yield, fast and efficient capture and isolation of extracellular vesicles from any liquid biopsy sample. The technology is highly scalable and is compatible with existing automated testing systems making it ideal for high volume research and commercial laboratory applications used in the analysis of proteins, lipids and nucleic acids.
Product features
