On 13 December 2022, INOVIQ announced that UQ had completed a 97-sample feasibility study confirming the utility of EXO-NET for exosome isolation, biomarker discovery and development of the EXO-OC test. A multivariate algorithm using selected EV biomarkers achieved 92% accuracy for detection of early-stage ovarian cancer (Stage I and II) in an independent sample set. This was the first milestone achieved under the collaboration with UQ to develop an exosomebased ovarian cancer screening test. The next step was an equivalence study to determine if the exosomal biomarkers discovered in plasma were also present in serum from the same patients. Substantial equivalence would facilitate access to a large ovarian cancer serum biobank for future studies. Post year-end (ASX: 9 August 2023), UQ completed a 250 paired-sample equivalence study to evaluate performance of the exosome-based biomarkers in plasma and serum samples from the same patients. The study demonstrated that whilst EXO-NET captured EVs from both plasma and serum, the samples from this long-term stored biobank (14-17 years) were not suitable for exosomal biomarker discovery and validation. INOVIQ plans to work with its collaborator UQ to source alternative samples for the further development and validation of the EXO-OC Test. Review of Operations BARD1 PROGRAM The BARD1 technology is a biomarker platform that includes potential BARD1 DNA, RNA, protein and autoantibody markers that have potential application in the earlier detection of breast, ovarian and lung cancers. Splice variants of BARD1 have been associated with cancer formation, progression, and poor prognosis. The BARD1 diagnostic program remains on hold as INOVIQ focuses its resources on advancing development of its promising SubB2M diagnostic and exosome diagnostic programs towards key milestones. BARD1 biomarkers may be included in biomarker panels of future pipeline products where they are shown to be informative of breast and ovarian cancer. INTELLECTUAL PROPERTY PORTFOLIO The Group owns or exclusively licenses a broad intellectual property (IP) portfolio of granted patents, patent applications, trade secrets and trademarks protecting INOVIQ’s technologies, products, processes and brands. The Group had 21 granted patents, 9 patents pending and 2 international provisional patent applications as at 30 June 2023, covering its SubB2M, Molecular NET, BARD1, and hTERT technologies and products across key jurisdictions including the United States, Europe, Asia, and Australia. Additionally, it owns registered trademarks for INOVIQ®, EXO-NET® and Acuris®. 16 INOVIQ Limited
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